The role of mitochondrial dysfunction in Alzheimer's disease

While Alzheimer's Disease is traditionally associated with the buildup of plaques, emerging evidence suggests that mitochondrial dysfunction may play a role in the onset and progression of this devastating neurodegenerative disorder.

Mitochondria, often referred to as the "powerhouses of the cell," are responsible for energy production and are vital for neuronal health. In Alzheimer's disease, impaired mitochondrial function disrupts essential processes, leading to a cascade of detrimental effects.

Researchers working with Domenico Praticò, MD, the Scott Richards North Star Foundation Chair for Alzheimer's Research, Professor of Neural Sciences and Founding Director of the Alzheimer's Center at Temple (ACT), at the Lewis Katz School of Medicine at Temple University (LKSOM), have published a review of studies that demonstrate the effects of mitochondrial dysfunction.

Changes such as altered electron transport chain activity, which increases production of reactive oxygen species (ROS), and oxidative stress affect cellular energy metabolism, calcium regulation, and apoptotic signaling, all of which are integral to the development of Alzheimer's.

The paper, "Mitochondrial dysfunction in Alzheimer's disease" is published in the journal Ageing Research Reviews.

More information:
Maria Clara Bila D'Alessandro et al, Mitochondrial dysfunction in Alzheimer's disease, Ageing Research Reviews (2025). DOI: 10.1016/j.arr.2025.102713

Provided by Alzheimer's Center at Temple University Lewis Katz School of Medicine